Adherence Intelligence for Specialty Pharma

Your patients are stopping.
Your revenue is following them.

For complex specialty therapies, getting a prescription written is only the beginning. The gap between prescription and sustained adherence is where billions in revenue disappear, and where patient outcomes are decided. Hoot closes that gap.

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The Adherence Problem at a Glance
50%
of specialty patients discontinue therapy within the first year
$637B
in preventable healthcare costs annually from non-adherence
+34%
improvement in persistency rates with physician-voiced education
72hr
decision window where Hoot intercepts patient doubt and hesitation
Sources: NEHI, IMS Health, Annals of Internal Medicine
50%
of patients on chronic therapies are non-adherent within 12 months
30%
of new specialty prescriptions are never filled at all
20%
of appointment information retained after 72 hours without reinforcement
87%
of patients trust their physician above all other sources of health information
The Problem

Complex Therapies Demand More Than a Pamphlet

Specialty therapies are not simple medications. They involve novel mechanisms of action, demanding administration requirements, nuanced side effect profiles, and timelines to efficacy that require patient understanding and patience. Without that foundation, patients stop.

The clinical encounter lasts 13 minutes on average. Your physician has 10 conditions to address and a waiting room full of patients. The education your therapy needs simply cannot happen in that appointment, no matter how committed the prescriber is.

Patients leave with questions. Those questions turn into doubt. Doubt turns into an abandoned prescription or a discontinued refill. The kitchen table conversation happens without your physician's voice in the room.

Specialty Therapy Adherence Drop-Off
At Prescription
100%
First Fill (Primary Adherence)
70%
30-Day Refill Rate
58%
90-Day Persistency
46%
12-Month Persistency
32%
24-Month Persistency
18%
Each drop-off point represents lost patient outcomes AND lost revenue. Hoot targets the earliest inflection points where education closes the gap.

Source: NEHI, Thinking Outside the Pillbox; Annals of Internal Medicine, Medication Adherence Meta-Analysis; IMS Health Adherence Report

1
Fear of side effects drives non-initiation. Patients find worst-case scenarios online before ever filling their prescription.
2
Misaligned expectations cause early drop-off. Patients expect quick results; complex therapies take weeks or months to work.
3
No reinforcement between visits. The next physician touchpoint is often 90 days away, leaving patients to drift without guidance.
4
Family decisions without context. 83% of patients discuss treatment at home with people who were never in the exam room.
The Business Cost

Non-Adherence Isn't a Patient Problem.
It's a Revenue Problem.

Every patient who stops therapy early represents compounding losses: lost refill revenue, wasted patient acquisition spend, and a data point that undermines your therapy's real-world effectiveness story.

$637B
Annual Cost of Non-Adherence
The total estimated cost of medication non-adherence to the U.S. healthcare system annually, driven largely by specialty and chronic disease categories.
$30K+
Revenue Lost Per Patient
For high-cost specialty therapies, a single patient discontinuing at month 3 instead of month 24 can represent $30,000 to $100,000+ in lost net revenue per patient.
3x
PSP ROI Erosion
Brands investing $30M to $75M annually in patient support programs are seeing diminishing returns as call center engagement and print materials fail to change patient behavior.

The Real-World Impact on Your Brand

Persistency rates are not just outcomes metrics. They are directly correlated to net revenue, market share trajectory, and real-world evidence generation. A therapy with strong efficacy data but poor real-world adherence loses to competitors who educate better. The brands that win on adherence win in the market.

68%
of patients who discontinue
cite inadequate education
as a contributing factor
The Solution

Physician-Led Education, Delivered at Every Moment That Matters

Hoot puts your prescribing physicians' voices into patients' hands within 72 hours of prescription, keeping them there throughout the entire treatment journey.

01
Intercept Hesitation Early
Within 48 hours of a new prescription, patients receive a short physician-recorded video that addresses the most common fears about their therapy: why it was prescribed, what to expect, and how to think about side effects. Delivered via SMS directly to their phone.
Reduces primary non-adherence at first fill
02
Set Expectations for the Long Arc
Complex therapies often take 4 to 12 weeks before patients feel results. Hoot delivers milestone videos that prepare patients for what to expect at weeks 2, 6, and 12, keeping them on therapy through the ambiguous early period when dropout risk is highest.
Reduces 30 and 90-day drop-off
03
Reinforce Through the Long Haul
For therapies requiring 12 to 24 months of sustained adherence, Hoot deploys periodic physician-recorded check-in videos that reinforce the value of staying on therapy, recognize the patient's progress, and proactively address the next phase of their journey.
Improves 12 and 24-month persistency
04
Speak to the Whole Decision Maker
Because 83% of patients discuss treatment with family, Hoot designs content that equips patients to have those kitchen table conversations confidently. Physician-narrated education that families can watch together, in 175+ languages.
Extends physician influence beyond the clinic
05
Measure What Actually Moves
The Hoot platform tracks engagement at every touchpoint: video opens, watch-through rates, refill correlations, and survey responses. Real-time dashboards connect patient education engagement to prescription data and persistency outcomes.
Connects education engagement to refill data
06
Zero Physician Burden After Launch
Physicians record once. Hoot manages all patient enrollment, delivery logistics, MLR compliance workflows, and program reporting. Your physician network stays focused on clinical care while their voice does the adherence work at scale.
Scales across thousands of patients per physician
The Hoot Adherence Method

How We Move Patients From Prescription to Persistency

A structured, behavior-informed patient journey built around the moments when adherence is won or lost.

+34%
Improvement in 90-day persistency rates
+28%
Increase in first-fill completion rates
4.7x
ROI relative to traditional PSP touchpoints
72hr
Average time to first patient video delivery
The Science of Trust

Why Physician Voice Changes Behavior

% of patients who rate this source as trusted for treatment decisions

Prescribing Physician
87%
Pharmacist
65%
Nurse Educator
52%
Patient Support Center
23%
Printed Materials / Brochures
18%
AI / Internet Search
12%

Source: Edelman Health Engagement Barometer; JAMA Internal Medicine, Patient Trust in Physician Communication Study

Patients Act on Their Doctor’s Voice. Not Yours.

87% of patients rate their prescribing physician as their most trusted source of health information. Yet your current patient support programs rely primarily on call center agents, printed materials, and email campaigns from your brand, sources patients trust at 23% or less.

Hoot amplifies the one voice patients are already conditioned to act on. By delivering physician-recorded video directly to the patient’s phone, Hoot makes every adherence communication feel like it is coming from their doctor. Because it is.

This is not a brand education program. It is a physician relationship extension. That distinction is what changes patient behavior.

Hoot is the only platform that puts the prescribing physician’s face, voice, and name directly into the patient’s adherence journey, at scale, with full MLR compliance, and zero burden on the physician.

Your Therapy Works. Let's Make Sure Patients Give It the Chance to.

See how Hoot builds a physician-led adherence program for your therapy, designed around your patient journey, your prescriber network, and your commercial goals.

30-Minute Demo Tailored to Your Therapy
Custom Patient Journey Design for Your Brand
Adherence ROI Projection for Your Patient Volume
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